Recombinant Rat IL-15 Synonyms: IL-T Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues. Catalog #: 400-24 Lot #: 1202279 Source: E.coli Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses Endotoxin level: Endotoxin level is less than 0.1 ng per mg (1EU/mg). Formulation: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in 50 mM Tris, pH 8.5 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use. Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20oC. Reconstituted IL-15 should be stored in working aliquots at - 20oC. Biological Activity: The ED50 was determined by the dose-dependent proliferation of murine CTLL-2 cells is < 10.0 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg.
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